The synthesis of substituted [1]benzothieno[2,3-c]quinolines and their N-methyl quaternary salts |
| |
Authors: | Jiann-Kuan Luo M. J. Musmar Raymond N. Castle |
| |
Abstract: | Four substituted [1]benzothieno[2,3-c]quinolines 14a-14d were prepared by photocyclization of the appropriate carboxamides 8a-8d to the corresponding [1]benzothieno[2,3-c]quinolin-6(5H)-ones 12a-12d followed by chlorination to 6-chloro[1]benzothieno[2,3-c]quinolines 13a-13d and dechlorination resulting in the title compounds. Treatment of 14a-14d with iodomethane furnished the corresponding N-methyl quaternary salts 5a-5d . |
| |
Keywords: | |
|
|