| 2-乙烯基取代8-羟基喹啉衍生物的合成及其抗氧化活性研究 |
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| 引用本文： | 张培全,曾和平,张卫民. 2-乙烯基取代8-羟基喹啉衍生物的合成及其抗氧化活性研究[J]. 化学通报, 2012, 0(1): 74-78 |
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| 作者姓名： | 张培全 曾和平 张卫民 |
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| 作者单位： | 广州医学院药学实验中心;华南理工大学化学科学学院功能分子研究所 |
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| 基金项目： | 国家自然科学基金项目(20671036);广东省科技项目(2006A10801002);广州医学院青年基金项目(L95115)资助 |
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| 摘 要： | 设计合成了2-[(2’-9H-芴-2-基)-乙烯基]-8-羟基喹啉(6)和2-[(2’-菲-9-基)-乙烯基]-8-羟基喹啉(7),通过IR、UV、1H NMR、MS和元素分析确认了其结构;并利用DPPH.方法、超氧阴离子自由基(O2.-)法、羟基自由基(OH.)法分别测定了目标产物的抗氧化活性。结果表明,这两种化合物对DPPH.、O 2.-和OH.都具有较强的抗氧化活性。
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| 关 键 词： | 2-[(2’-芴基)-乙烯基]-8-羟基喹啉 2-[(2’-菲基)-乙烯基]-8-羟基喹啉 抗氧化活性 |
Synthesis of 2-Vinyl-8-hydroxyquinolin Derivatives and Their Antioxidation Activities |
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| Zhang Peiquan,Zeng Heping,Zhang Weimin. Synthesis of 2-Vinyl-8-hydroxyquinolin Derivatives and Their Antioxidation Activities[J]. Chemistry, 2012, 0(1): 74-78 |
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| Authors: | Zhang Peiquan Zeng Heping Zhang Weimin |
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| Affiliation: | 1Laboratory Center of Pharmaceutical Sciences,Guangzhou Medical College,Guangzhou 510182;2Institute of Functional Molecules,Faculty of Chemistry,South China University of Technology,Guangzhou 510641) |
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| Abstract: | 2-(2-(9H-fluoren-2-yl)vinyl)-8-hydroxyquinoline(6) and 2-(2-(phenanthren-9-yl)vinyl)-8-hydroxyquinoline(7) have been synthesized.The structure of compounds 6 and 7 were confirmed by UV-Vis,FT-IR,ESI-MS,1HNMR and elemental analysis.Meanwhile,the antioxidation activities of the titled compounds have been investigated by the DPPH·,O-·2 and OH·methods.The results showed that the titled compounds have strong antioxidation activity to the DPPH·,O-·2 and OH· free radicals. |
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| Keywords: | 2-(2-(9H-Fluoren-2-yl)vinyl)-8-hydroxyquinoline 2-(2-(Phenanthren-9-yl)vinyl)-8-hydroxyquinoline Antioxidation activity |
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