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Synthesis of sulfur-substituted phosphatidylethanolamines and inhibition of protozoan cyclopropane fatty acid synthase |
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| Affiliation: | 1. Gastroenterology and Hepatology Department, Hospital Universitario Ramón y Cajal, Spain;2. Pathological Anatomy Department, Hospital Universitario Ramón y Cajal, Spain;1. Organic Synthesis & Process Chemistry Division, CSIR-Indian Institute of Chemical Technology, Hyderabad, 500 007, Telangana, India;2. Academy of Scientific and Innovative Research (AcSIR), New Delhi, 110 025, India |
| Abstract: | A phosphalidylethanolamine(it1) containing two 9- thiastearyl groups was prepared by chemical synthesis. This compound and its methyl sulfonium derivative were found to be inhibitors of the cyclopropane fatty acid synthase from parasitic protozoan Crithidia fasciculata. |
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