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Novel (thio)barbituric-phenoxy-N-phenylacetamide derivatives as potent urease inhibitors: synthesis,in vitro urease inhibition,and in silico evaluations |
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| Authors: | Sedaghati Saeb Azizian Homa Montazer Mohammad Nazari Mohammadi-Khanaposhtani Maryam Asadi Mehdi Moradkhani Fatemeh Ardestani Mehdi Shafiee Asgari Mohammad Sadegh Yahya-Meymandi Azadeh Biglar Mahmood Larijani Bagher Sadat-Ebrahimi Seyed Esmaeil Foroumadi Alireza Amanlou Massoud Mahdavi Mohammad |
| Institution: | 1.Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, Iran ;2.Department of Medicinal Chemistry, School of Pharmacy-International Campus, Iran University of Medical Sciences, Tehran, Iran ;3.Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran ;4.Department of Radiopharmacy and Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran ;5.School of Chemistry, College of Science, University of Tehran, Tehran, Iran ;6.Department of Chemistry, Faculty of Science, University of Birjand, Birjand, Iran ;7.Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran ; |
| Abstract: | Structural Chemistry - A novel series of (thio)barbituric-phenoxy-N-phenylacetamide derivatives 7a-l was synthesized and evaluated against Helicobacter pylori urease. The latter assay revealed that... |
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