|
|||||
|
|
A combined structure-based pharmacophore modeling and 3D-QSAR study on a series of N-heterocyclic scaffolds to screen novel antagonists as human DHFR inhibitors |
|
| Authors: | Hariri Safoura Rasti Behnam Shirini Farhad Ghasemi Jahan B |
| Institution: | 1.Department of Chemistry, College of Science, University of Guilan, Rasht, Iran ;2.Department of Microbiology, Faculty of Basic Sciences, Lahijan Branch, Islamic Azad University (IAU), Lahijan, Guilan, Iran ;3.Faculty of Chemistry, University of Tehran, Tehran, Iran ; |
| Abstract: | Structural Chemistry - Dihydrofolate reductase (DHFR) is an essential enzyme that participates in folate metabolism and purine and thymidylate synthesis in cell proliferation. It converts... |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ | |