Synthesis of some thiopyrimidine and thiazolopyrimidines starting from 2,6-dibenzylidene-3-methylcyclohexanone and its antimicrobial activities |
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| Authors: | Usama W Hawas Mohamed A Al-Omar Abdel Galil E Amr Abu El-Ftouh G Hammam |
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| Institution: | 1. Applied Organic Chemistry Department, National Research Center, Dokki, Cairo, Egypt;2. Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia |
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| Abstract: | A series of novel N-substituted arylidene, pyrazole, thioxopyrimidine and thiazolopyrimidine derivatives 2–7 were synthesized by initial reactions of 2-methyl-cyclohexanone with aromatic aldehydes to give 2,6-dibenzylidene-3-methylcyclohexanone 2. Some of the synthesized compounds were tested as antimicrobial agents. The detailed synthesis, spectroscopic data, and antimicrobial activities of the synthesized compounds were reported. |
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| Keywords: | 2 6-Dibenzylidene-3-methyl-cyclohexanone Thiopyrimidine Thiazolopyridine Antimicrobial agents |
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