Syntheses,Structural, and Biological Studies of Two New Peptide Compounds, 2(s)-(5-fluorouracil-1-aceto)amino-2-isopropyl Acetate Hemihydrate and 2(s)-(5-fluorouracil-1-aceto)amino-2-isopropyl Acetic Acid

Abstract  Two new peptide compounds, 2(s)-(5-fluorouracil-1-aceto)amino-2-isopropyl acetate hemihydrate (1:1/2H ₂ O) and 2(s)-(5-fluorouracil-1-aceto)amino-2-isopropyl acetic acid (2), have been synthesized and characterized by elemental analysis, IR, ¹H- and ¹³C NMR spectroscopy. Two new compounds were structurally characterized by single-crystal X-ray diffraction. The thermal stabilities of compounds 1:1/2H ₂ O and 2 were studied by DSC-TGA techniques. The result of the biological test showed that the compounds 1:1/2H ₂ O and 2 have certain antitumor activities. Index Abstract  Two new peptide compounds, 2(s)-(5-fluorouracil-1-aceto)amino-2-isopropyl acetate hemihydrate (1:1/2H2O) and 2(s)-(5-fluorouracil-1-aceto)amino-2-isopropyl acetic acid (2), have been synthesized and characterized by elemental analysis, IR, 1H-, and 13C NMR spectroscopy. Two new compounds were structurally characterized by single-crystal X-ray diffraction. The thermal stabilities of compounds 1:1/2H2O and 2 were studied by DSC-TGA techniques. The result of the biological test showed that the compounds 1:1/2H2O and 2 have certain antitumor activities.