Synthesis,structural and conformational study of selected <Emphasis Type="Italic">N</Emphasis>-substituted phthalimides

This paper synthesizes N-substituted phthalimides derived from nitrogen heterocycles as potential 5-HT₄ ligands by using the Mitsunobu reaction. Conformational studies of some of the new compounds have been conducted using ¹H and ¹³C-NMR spectroscopy. Proton and carbon resonances were achieved through the application of one-dimensional selective NOE, two-dimensional NMR techniques-homonuclear COSY-45, NOESY and heteronuclear ¹H-¹³C HMQC correlated spectroscopy- and double resonance experiments. The crystal structure of compound 1 was determined by X-ray diffraction.