| Reduction of Azide to Amine Using Fe/AlCl3 or Fe/BiCl3 System in Aqueous EtOH |
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| 作者姓名： | 郑鹏武 段学民 王伟 王晓季 郭玉萍 涂其冬 |
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| 作者单位： | [1]School of Pharmacy, Jiangxi Science and Technology Normal University, Nanchang, Jiangxi 330013, China [2]School of Chemical Engineering, Anshan University of Science and Technology, Anshan, Liaoning 114044, China |
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| 基金项目： | Project supported by the Science Funds of the Education 0ffice of Jiangxi, China （No. [2006]246）. |
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| 摘 要： | Azides were reduced to the corresponding amines by two new metal/Lewis acid systems in aqueous EtOH with yields ranging from 80% to 95%. The new reduction systems were Fe/AlCl3·6H2O or Fe/BiCl3 system in H2O/ethanol （2 ： 1, Ⅴ ：Ⅴ） at room temperature. Fifteen azides with different functional groups were well reduced to the corresponding amines in excellent yields.
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| 关 键 词： | 叠氮化物 还原 胺 氨基化合物 Fe/AlCl3体系 Fe/BiCl3体系 |
| 收稿时间： | 2005-07-11 |
| 修稿时间： | 2005-07-112006-02-09 |
Reduction of Azide to Amine Using Fe/AlCl3 or Fe/BiCl3 System in Aqueous EtOH |
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| ZHENG Peng-Wu,DUAN Xue-Min,WANG Wei,WANG Xiao-Ji,GUO Yu-Ping,TU Qi-Dong.Reduction of Azide to Amine Using Fe/AlCl3 or Fe/BiCl3 System in Aqueous EtOH[J].Chinese Journal of Chemistry,2006,24(6):825-826. |
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| Authors: | ZHENG Peng-Wu DUAN Xue-Min WANG Wei WANG Xiao-Ji GUO Yu-Ping TU Qi-Dong |
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| Abstract: | Azides were reduced to the corresponding amines by two new metal/Lewis acid systems in aqueous EtOH with yields ranging from 80% to 95%. The new reduction systems were Fe/AlCl3·6H2O or Fe/BiCl3 system in H2O/ethanol (2:1, V:V) at room temperature. Fifteen azides with different functional groups were well reduced to the corresponding amines in excellent yields. |
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| Keywords: | azide reduction amine amide |
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