首页 | 本学科首页   官方微博 | 高级检索  
     检索      


Access to 2‐Arylindoles via Decarboxylative C−C Coupling in Aqueous Medium and to Heteroaryl Carboxylates under Base‐Free Conditions using Diaryliodonium Salts
Authors:Velladurai Arun  Meenakshi Pilania  Prof Dalip Kumar
Institution:1. http://universe.bits‐pilani.ac.in/pilani/dalipk/profile;2. Department of Chemistry, Birla Institute of Technology and Science, Pilani-, Rajasthan, India;3. (+91)?1596‐244183
Abstract:Easily accessible heteroaromatic carboxylic acids and diaryliodonium salts were successfully employed to construct valuable 2‐arylindoles and heteroaryl carboxylates in a regioselective fashion. C2‐arylated indoles were produced using a Pd‐catalyzed decarboxylative strategy in water without any base, oxidant, or ligand. Heteroaryl carboxylates were prepared under metal and base‐free conditions. This protocol was successfully utilized to synthesize Paullone, a cyclin‐dependent kinase (CDK) inhibitor.
Keywords:arylation  C−  C coupling  diaryliodonium salt  heterocycles  homogeneous catalysis
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号