| 末端炔烃、炔醇的制备及其进一步的烷基化反应 |
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| 引用本文： | 许临晓,陶凤岗,吴钧和. 末端炔烃、炔醇的制备及其进一步的烷基化反应[J]. 有机化学, 1984, 0(2) |
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| 作者姓名： | 许临晓 陶凤岗 吴钧和 |
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| 作者单位： | 复旦大学化学系 上海 |
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| 摘 要： | 二氯甲基膦酸二乙酯与醛反应,制得1,1-二氯代烯烃。再用丁基锂处理,水解后得到末端炔烃。若进一步与醛或环氧化合物反应可得到相应的炔醇。中间体1,1-二氯代烯烃不经分离,与过量的丁基锂作用,可发生进一步的烷基化反应。文中还讨论了上述反应结果和可能的机理。
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| 关 键 词： | 炔烃(P) 一元醇 环己烯(P) 烷基化 制备 反应机理 |
Synthesis via 1,1-Dichloroalkenes and Further Alkylations of Terminal Alkynes and Alkynols |
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| Xu Linxiao,Tao Fenggang,Wu Junhe. Synthesis via 1,1-Dichloroalkenes and Further Alkylations of Terminal Alkynes and Alkynols[J]. Chinese Journal of Organic Chemistry, 1984, 0(2) |
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| Authors: | Xu Linxiao Tao Fenggang Wu Junhe |
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| Affiliation: | Xu Linxiao,Tao Fenggang,Wu Junhe Department of Chemistry,Fudan University,Shanghai |
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| Abstract: | 1,1-Dichloroalkenes,obtained by reactions of dichloromethanephosphonatewith aldehydes,were treated with n-butyl lithium followed by hydrolysis to yield termi-nal alkynes,which may further react with another aldehyde (or epoxide) to yield alky-nols.Isolation of the intermediate 1,1-dichloroalkenes is unnecessary.Alkylated prod-ucts may be obtained with excess of n-butyl lithium.The possible reaction mechanism issuggested and discussed in this paper. |
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| Keywords: | alkyne (P) monohydric alcohol cyclohexene(P) alkylation preparation reaction mechanism. |
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