Reduction of dioxygen catalyzed by pyrene-wired heme domain cytochrome P450 BM3 electrodes |
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Authors: | Udit Andrew K Hill Michael G Bittner V Garrett Arnold Frances H Gray Harry B |
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Institution: | Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, USA. |
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Abstract: | We have electronically wired the cytochrome P450 BM3 heme domain to a graphite electrode with the use of a pyrene-terminated tether. AFM images clearly reveal that pyrene-wired enzyme molecules are adsorbed to the electrode surface. The enzyme-electrode system undergoes rapid and reversible electron transfer, displaying a standard rate constant higher than that of any other P450-electrode system. We also show that the graphite-pyrene-BM3 system catalyzes the four-electron reduction of dioxygen to water. |
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