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Molecular interactions between lipid bilayers and a water-soluble polymer
Authors:Ayumi Yoshida  Hitoshi Yamauchi  Hideki Sakai  Norimichi Kawashima  Masahiko Abe
Affiliation:

a Faculty of Science and Technology, Science University of Tokyo, 2641, Yamazaki, Noda, Chiba 278, Japan

b Institute of Colloid and Interface Science, Science University of Tokyo, 1–3, Kagurazaka, Shinjuku, Tokyo 162, Japan

c Materials Science and Technology Department, Toin University of Yokohama, 1614 Kurogane, Aoba, Yokohama 225, Japan

Abstract:Molecular interactions between lipid bilayers (liposomes) and chondroitin sulfate C (CS), a water soluble polymer, have been investigated in terms of zeta-potential, particle size, microscopic-viscosity, microscopic-polarity of liposomes and permeability of calcein. Microscopic morphology is dramatically changed by the addition of CS to the positively charged liposomes (Pos.L), while it is not changed by the addition to uncharged liposomes (Unc.L) or negatively charged liposomes (Neg.L). The absolute value of the particle size of Pos.L increases with the addition of CS, while the zeta- potential of Pos.L decreases. Permeability of Pos.L decreases with an increase in the concentration of CS. Phase transition temperature of Pos.L is changed after the addition of CS. These values, however, are not changed for the other liposomes by the addition of CS. The results of gel filtration chromatography show that CS is absorbed on the Pos.L surface. Microscopic viscosity is also increased by the addition of CS to Pos.L due to the adsorption of CS.
Keywords:Adsorption   Chondroitin sulfate   Liposomes   Microscopic-viscosity   Permeability
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