| Abstract: | An accurate, simple, fast, and cheap spectrophotometric method has been developed for the determination of lisinopril in pharmaceutical pure and dosage forms. The method is based on the reaction of ninhydrin with primary amine present in the lisinopril in the presence of DMF. This reaction produces a greenish blue colored product which absorbs maximally at 600 nm. Beer's law was obeyed in the range of 10–150 μg/mL with molar absorptivity of 4.083 × 103 L mole?1 cm?1. The effects of variables such as temperature, heating time, concentration of color producing reagent, and stability of color were investigated to optimize the procedure. The results are validated statistically. The proposed method was applied to commercially available tablets, and the results were statistically compared with the official potentiometric method. |
