Rapid synthesis of 2,5‐disubtituted 1,3,4‐thiadiazoles under microwave irradiation |
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Authors: | Mounim Lebrini,Fouad Bentiss,Michel Lagren e |
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Affiliation: | Mounim Lebrini,Fouad Bentiss,Michel Lagrenée |
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Abstract: | The one pot, three‐components condensation of aromatic aldehydes, hydrazine and sulfur in ethanol under microwave irradiation provided symmetrically 3,5‐disubstituted 1,3,4‐thiadiazoles in high yields and good purity. This reaction must be conducted under pressure of hydrogen sulfide produced in‐situ. The structure of the compounds was confirmed by 1H, 13C NMR, MS and elemental analysis. |
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