1,6‐ and 1,7‐naphthyridines. IV. Synthesis of hydroxycarboxamide derivatives |
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Authors: | M Mercedes Blanco Celia B Schapira Gustavo Levin Isabel A Perillo |
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Abstract: | A series of 8‐hydroxy‐1,6‐naphthyridin‐5(6H)‐one‐7‐carboxamides 1 and the isomeric 5‐hydroxy‐1,7‐naphthyridin‐8(7H)‐one‐6‐carboxamides 2 were synthesized. N‐Lactam unsubstituted compounds 1a‐c and 2a,b were obtained by alkoxide‐induced rearrangement of the corresponding quinolinimidoacetamides 3 . Compounds 1e,f and 2e,f were synthesized by heterocyclization of the corresponding quinolinamic esters 6 and 7 . Spectroscopic properties (uv, ir, 1H and 13C nmr and ms) were analyzed and the proposed structures confirmed. |
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