Regiospecific synthesis,structure and electron ionization mass spectra of 1,3‐thiazolidin‐4‐ones containing the acridine skeleton |
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| Authors: | Imrich G ci,J n Imrich,Pavol Kristian,Henri Kivel ,Pauliina Valtamo,Kalevi Pihlaja |
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| Affiliation: | Imrich Géci,Ján Imrich,Pavol Kristian,Henri Kivelä,Pauliina Valtamo,Kalevi Pihlaja |
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| Abstract: | The synthesis of regioisomeric 3‐alkyl(aryl)‐2‐(acridin‐9′‐yl)imino‐1,3‐thiazolidin‐4‐ones ( 8b‐i ) and 2‐alkyl(aryl)imino‐3‐(acridin‐9′‐yl)‐1,3‐thiazolidin‐4‐ones ( 11a‐i ) was performed by the reaction of 3‐(acridin‐9‐yl)‐1‐alkyl(aryl)thioureas 5a‐i with methyl bromoacetate and bromoacetyl bromide, respectively, via the corresponding isothiourea hydrobromides with excellent regioselectivity. The structure, NMR spectra and mass spectrometric behavior of the resulting compounds are discussed. |
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