Synthesis of one‐, two‐ and three‐ring macrocyclic,bifunctional compounds for use in radiolabelling monoclonal antibodies

The synthesis of new linked bis‐ and tris‐ring tetraazamacrocyclic (bifunctional) reagents for use in an alternative strategy for radiolabelling antibodies is described. For comparison with the above systems, a new single ring bifunctional system incorporating a dioxocyclam ring is also reported.