A new derivative of triterpene with anti-melanoma B16 activity from Conyza Canadensis |
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Authors: | Ming Ming Yan Ting You Li Da Qing Zhao Shuai Shao Sheng Nan Bi |
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Institution: | a Changchun University of Chinese Medicine, Changchun 130117, China;b School of Pharmacy, Nanjing Medical University, Nanjing 210029, China |
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Abstract: | A new derivative of triterpene named Erigeronol 1 was isolated from the EtOH extract of the aerial part of Conyza canadensis together with fifteen known compounds for the first time from this plant. The structure of Erigeronol 1 was elucidated as 3-O-(hydroxy-acetyl)-23,28-dihydroxy-β-amyrin by hydrolysis and spectroscopic analysis. Erigeronol 1 showed potent cytotoxic activity with IC50 value of 7.77±0.47 μg/mL against melanoma B16 determined by the 3-(4,5-dimethylthiazo-2-yl)-2,5-diphenyltetrazolium bromide (MTT) method. |
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Keywords: | Conyza canadensis Derivative of triterpene Anti-melanoma B16 |
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