Synthesis, characterization and DNA-binding studies of ruthenium(II) mixed-ligand complexes containing dipyrido[1,2,5]oxadiazolo[3,4-b]quinoxaline |
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| Authors: | Bin Peng Xiang Chen Ke-Jie Du Bo-Le Yu Hui Chao Liang-Nian Ji |
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| Affiliation: | aMOE Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry and Chemical Engineering, Sun Yat-Sen University, Guangzhou 510275, PR China;bSchool of Chemistry and Chemical Engineering, Hunan University of Science and Technology, Xiangtan 411201, PR China |
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| Abstract: | A novel ligand dipyrido[1,2,5]oxadiazolo[3,4-b]quinoxaline (dpoq) and its complexes [Ru(bpy)2(dpoq)]2+ and [Ru(phen)2(dpoq)]2+ (bpy = 2,2′-bipyridine; phen = 1,10-phenanthroline) have been synthesized and characterized by elemental analysis, electrospray mass spectra and 1H NMR. The interaction of Ru(II) complexes with calf thymus DNA (CT-DNA) was investigated by absorption spectroscopy, fluorescence spectroscopy, thermal denaturation and viscosity measurements. Results suggest that two Ru(II) complexes bind to DNA via an intercalative mode. |
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| Keywords: | Ru(II) complexes Polypyridine ligands DNA-binding |
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