| 手性氨基醇催化的苯乙炔与酮的对映选择性加成 |
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| 引用本文： | 丁娟,沈宗旋,罗晓清,陈维一,张雅文. 手性氨基醇催化的苯乙炔与酮的对映选择性加成[J]. 中国化学, 2006, 24(10): 1285-1289. DOI: 10.1002/cjoc.200690239 |
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| 作者姓名： | 丁娟 沈宗旋 罗晓清 陈维一 张雅文 |
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| 作者单位： | Key Laboratory of Organic Synthesis of Jiangsu Province College of Chemistry and Chemical Engineering，Suzhou University，Suzhou，Jiangsu 215006，China，Key Laboratory of Organic Synthesis of Jiangsu Province，College of Chemistry and Chemical Engineering，Suzhou University，Suzhou，Jiangsu 215006，China，Suzhou Health School，Suzhou，Jiangsu 215007，China，Key Laboratory of Organic Synthesis of Jiangsu Province，College of Chemistry and Chemical Engineering，Suzhou University，Suzhou，Jiangsu 215006，China，Key Laboratory of Organic Synthesis of Jiangsu Province，College of Chemistry and Chemical Engineering，Suzhou University，Suzhou，Jiangsu 215006，China |
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| 基金项目： | Project supported by the Key Laboratory of Organic Synthesis of Jiangsu Province(No.JSK015). |
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| 摘 要： | (S)-(1-Benzylpyrrolidin-2-yl)diphenylmethanol and cinchonine were evaluated as promotors in the asymmetricadditions of phenylacetylene to ketones,in order to prepare chiral propargylic alcohols.Good yields(up to 89%)and moderate enantioselectivities(up to 77.9% ee)were achieved.Addition of Ti(OPr-i)_4 can significantly improvethe enantioselectivity of the reaction.
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| 关 键 词： | 手性氨基醇 对映选择加成 苯基乙炔 酮 弱金鸡纳碱 |
| 收稿时间： | 2005-12-01 |
| 修稿时间： | 2005-12-012006-07-19 |
Enantioselective Addition of Phenylacetylene to Ketones Catalyzed by Chiral Amino Alcohols |
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| DING Juan, SHEN Zong-Xuan, LUO Xiao-Qing, CHEN Wei-Yi, ZHANG Ya-Wen. Enantioselective Addition of Phenylacetylene to Ketones Catalyzed by Chiral Amino Alcohols[J]. Chinese Journal of Chemistry, 2006, 24(10): 1285-1289. DOI: 10.1002/cjoc.200690239 |
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| Authors: | DING Juan SHEN Zong-Xuan LUO Xiao-Qing CHEN Wei-Yi ZHANG Ya-Wen |
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| Affiliation: | 1.Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry and Chemical Engineering, Suzhou University, Suzhou, Jiangsu 215006, China;2.Suzhou Health School, Suzhou, Jiangsu 215007, China |
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| Abstract: | (S)-(1-Benzylpyrrolidin-2-yl)diphenylmethanol and cinchonine were evaluated as promotors in the asymmetric additions of phenylacetylene to ketones,in order to prepare chiral propargylic alcohols.Good yields(up to 89%) and moderate enantioselectivities(up to 77.9% ee)were achieved.Addition of Ti(OPr-i)_4 can significantly improve the enantioselectivity of the reaction. |
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| Keywords: | chiral amino alcohol enantioselective addition phenylacetylene cinchonine |
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