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In vitro dissolution study of uranium dioxide and uranium ore with different particle sizes in simulated lung fluid |
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| Authors: | Weijia Li R Skinner K Megna Jing Chen S Perera J Murimboh E Waller L Erhardt R J Cornett |
| Institution: | (1) Radiation Protection Bureau, Health Canada, A.L.:6302D1, 775 Brookfield Rd, Ottawa, ON, K1A 1C1, Canada;(2) School of Energy Engineering and Nuclear Science, University of Ontario Institute Technology, 2000 Simcoe Street, North Oshawa, ON, L1H 7K4, Canada;(3) Department of Chemistry, Acadia University, Wolfville, Nova Scotia, B4P 2R6, Canada;(4) Defence R&D Canada — Ottawa, 3701 Carling Ave., Ottawa, ON, K1A 0Z4, Canada |
| Abstract: | Inhalation is one of the most important routes for aerosol particles of uranium compounds to enter the body. The main step for uranium to be available for blood circulation and for interaction with bio-molecules is the dissolution of the particles. Particle size effects on dissolution of uranium dioxide and uranium ore were studied in simulated lung fluid using the “batch/filter” method. Samples were fractionated to ten size ranges from <0.43 μm to >10 μm by cascade impaction prior to dissolution experiments. Dependence of dissolution kinetics on particle size and on the amount of uranium trioxide contained in the particles was observed. |
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