An in situ approach for nickel-catalyzed cycloaddition |
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Authors: | Tekavec Thomas N Zuo Gang Simon Kristina Louie Janis |
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Institution: | Department of Chemistry, University of Utah, 315 South 1400 East, Salt Lake City, Utah 84112, USA. |
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Abstract: | A convenient method for preparing pyridines from air-stable, commercially available catalyst precursors is described. The addition of n-BuLi to Ni(acac)2 and an NHC salt (such as IPr.HCl or SIPr.HCl) rapidly generates an active Ni0/NHC catalyst for the cycloaddition of diynes and nitriles that affords pyridines without a decrease in observed yields. The in situ method also converts diynes and carbon dioxide to the corresponding pyrones. |
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