| Studies on the Synthesis of Penazetidine A, an Alkaloid Inhibitor of Protein Kinase C |
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| 引用本文： | ZhiMingLI BingWANG FengGangTAO GuoQiangLIN. Studies on the Synthesis of Penazetidine A, an Alkaloid Inhibitor of Protein Kinase C[J]. 中国化学快报, 2004, 15(2): 138-140 |
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| 作者姓名： | ZhiMingLI BingWANG FengGangTAO GuoQiangLIN |
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| 作者单位： | [1]DepartmentofChemistry,FudanUniversity,Shanghai200433 [2]ShanghaiInstituteofOrganicChemistry,ChineseAcademyofSciences,Shanghai200032 |
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| 摘 要： | A convergent asymmetric synthesis of (2S, 3R, 4S, 12′R)-3-hydroxy-2-hydroxymethyl-4-(12′-methyloctadecyl)-N-（p-tolylsulfonyl)-azetidine, a key precursor of penazetidine A, has been achieved by starting from divinylcarbinol.
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| 关 键 词： | 合成 生物碱抑制剂 蛋白激酶C penazetidine A 维蒂希反应 吖丁啶 |
Studies on the Synthesis of Penazetidine A, an Alkaloid Inhibitor of Protein Kinase C |
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| Zhi Ming LI,Bing WANG,Feng Gang TAO,Guo Qiang LIN. Studies on the Synthesis of Penazetidine A, an Alkaloid Inhibitor of Protein Kinase C[J]. Chinese Chemical Letters, 2004, 15(2): 138-140 |
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| Authors: | Zhi Ming LI Bing WANG Feng Gang TAO Guo Qiang LIN |
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| Affiliation: | Zhi Ming LI1,Bing WANG2,Feng Gang TAO1*,Guo Qiang LIN2* 1Department of Chemistry,Fudan University,Shanghai 200433 2Shanghai Institute of Organic Chemistry,Chinese Academy of Sciences,Shanghai 200032 |
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| Abstract: | A convergent asymmetric synthesis of (2S, 3R, 4S, 12'R)-3-hydroxy-2-hydroxymethyl- 4-(12' -methyloctadecyl)-N-(p-tolylsulfonyl)-azetidine, a key precursor of penazetidine A, has been achieved by starting from divinylcarbinol. |
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| Keywords: | Penazetidine A alkaloid azetidine Wittig reaction. |
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