Photoswitched DNA-binding of a photochromic spiropyran |
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Authors: | Andersson Johanna Li Shiming Lincoln Per Andréasson Joakim |
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Affiliation: | Department of Chemical and Biological Engineering, Physical Chemistry, Chalmers University of Technology, SE-412 96 G?teborg, Sweden. |
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Abstract: | The dramatically different DNA-binding properties of the two isomeric forms of a photochromic spiropyran have been demonstrated, enabling photoswitched DNA binding. The closed, UV-absorbing form shows no signs of interaction with DNA. Upon UV exposure the spiropyran is isomerized to the open form that binds to DNA by intercalation. The process is fully reversible as the corresponding dissociation process is induced by visible light. |
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