Synthesis of carbapyochelins via diastereoselective azidation of 5-(ethoxycarbonyl)methylproline derivatives |
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| Authors: | Liyanage Wathsala Weerasinghe Laksiri Strong Roland K Del Valle Juan R |
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| Affiliation: | Department of Chemistry and Biochemistry, New Mexico State University, MSC3C, Las Cruces, New Mexico 88003, USA. |
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| Abstract: | Two configurationally stable carbon-based analogues of pyochelin have been prepared from Boc-pyroglutamic acid-tert-butyl ester in 11 and 13 steps. Introduction of the amino group was achieved by a highly diastereoselective electrophilic azidation reaction to afford novel bis-alpha-amino acid proline derivatives. |
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