Synthesis of a sialic acid derivative of ristocetin aglycone as an inhibitor of influenza virus |
| |
| Authors: | Ilona Bakai-Bereczki Mihály Herczeg Bernadett György Lieve Naesens Pál Herczegh |
| |
| Institution: | 1.Department of Pharmaceutical Chemistry, Faculty of Pharmacy,University of Debrecen,Debrecen,Hungary;2.Rega Institute for Medical Research,KU Leuven,Leuven,Belgium |
| |
| Abstract: | In order to promote attachment of the ristocetin aglycone molecule to the surface of the influenza virus, the aglycone was derivatized with a hemagglutinin ligand sialic acid moiety using a click reaction. The sialoristocetin derivative exhibited somewhat lower anti-influenza virus activity than ristocetin and aglycoristocetin. |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
