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Comparison of bacteriolytic activity of human interleukin-2 and chicken egg lysozyme on |
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| Authors: | P. A. Levashov D. A. Matolygina H. E. Osipova S. S. Savin G. S. Zaharova D. A. Gasanova N. G. Belogurova E. D. Ovchinnikova S. A. Smirnov V. I. Tishkov A. V. Levashov |
| Affiliation: | 1.Department of Chemistry,Moscow State University,Moscow,Russia;2.Russian Cardiology Research and Scientific Production Complex,Ministry of Health and Social Development of the Russian Federation,Moscow,Russia;3.Bach Institute of Biochemistry,Research Center of Biotechnology of the Russian Academy of Sciences,Moscow,Russia |
| Abstract: | The article continues studies of the recently discovered bacteriolytic activity of interleukin-2. It was detected earlier that interleukin (IL-2) possesses greater substrate specificity in comparison with chicken egg lysozyme. IL-2 disrupted the cell wall of Escherichia coli but did not lyse lysozyme substrates such as the cell walls of Micrococcus luteus and Bacillus subtilis. In the present study it is demonstrated for the first time that both IL-2 and chicken egg lysozyme are capable of lysing Lactobacillus plantarum. The effects of IL-2 and chicken egg lysozyme on Lactobacillus plantarum are compared with those on Escherichia coli. The dependences of the rate of lysis on the concentration of bacteriolytic factors and pH are studied. |
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