Catalytic asymmetric coupling of 2-naphthols by chiral tridentate oxovanadium (IV) complexes |
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| Authors: | Hon S W Li C H Kuo J H Barhate N B Liu Y H Wang Y Chen C T |
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| Institution: | Department of Chemistry, National Taiwan Normal University, and Instrumentation Center, College of Science, National Taiwan University, Taipei, Taiwan, R.O.C. |
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| Abstract: | A series of chiral oxovanadium(IV) complexes derived from tridentate N-3,5-substituted and N-3,4-benzo- and N-5,6-benzo-salicylidene-alpha-amino acids can serve as efficient catalysts for the enantioselective oxidative couplings of various 3-, 6-, and 7-substituted 2-naphthols under O(2). The best scenario involves the use of a vanadyl complex arising from 2-hydroxy-1-naphthaldehyde and valine (or phenylalanine) in CCl(4), leading to BINOLs in good yields (75-100%) and with enantioselectivities of up to 68%. |
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