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Determination of Boanmycin in Pharmaceutical Preparations by a Simple and Rapid Ion-pair LC Method |
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| Authors: | Yu Liu Sun Dong Yoo Liang Fang Xin Jin Li Li YanJun Ren ChongShun Yao TieFu Li |
| Institution: | 1. School of Pharmacy, Shenyang Pharmaceutical University, 110016, Shenyang, Liaoning, China 2. College of Pharmacy, Sungkyunkwan University, Suwon, 440-746, Korea 3. Dikang Pharmaceutical Co., Ltd, 136600, Liaoyuan, Jilin, China 4. School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, 110016, Shenyang, Liaoning, China |
| Abstract: | An ion-pair HPLC method with UV detection is described for the determination of boanmycin in freeze-dried pharmaceutical preparations. Chromatographic separation was achieved on a 5 μm Agilent Eclipse XDB-C18 column (150 × 4.6 mm). The mobile phase contained methanol, acetonitrile, 055 M sodium hexanesulfonate and 0.08 M acetic acid in water. UV detection was at 291 nm. The assay was validated over a linear concentration range from 0.05 to 120 μg mL?1. The method was applied to determine the content of BAM in freeze-dried powders. |
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