Simultaneous Determination of Benzodiazepines and Ketamine from Alcoholic and Nonalcoholic Beverages by GC-MS in Drug Facilitated Crimes |
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Authors: | Munevver Acikkol Selda Mercan Sukriye Karadayi |
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Affiliation: | 1. Institute of Forensic Sciences, Istanbul University, 34303, Istanbul, Turkey
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Abstract: | A GC-MS method with HP-5MS capillary column was developed for the simultaneous determination of underivatized flunitrazepam, clonazepam, alprazolam, diazepam and ketamine from drinks by extraction with chloroform: isopropanol 1:1 (v/v). All linearity ranges were between 50 and 1,000 μg mL?1 for all compounds both in beer and in peach juice. Limit of detection was between 1.3 and 34.2 μg mL?1, limit of quantification was between 3.9 and 103.8 μg mL?1, the range of recoveries was 73.0 and 112.6% for all drugs in both beverages. The reported method was sensitive, rapid, and suitable for the analysis of the spiked drinks as evidence of sexual assault and robbery phenomena. |
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