Anhydrous α-lactose A study with DSC and TXRD |
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Authors: | L. O. Figura M. Epple |
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Affiliation: | 1. Deutsches Institut für Lebensmitteltechnik e. V., 49610, Quakenbrück, Germany 2. Department of Chemical Engineering, University of Washington, Seattle, USA
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Abstract: | The dehydrated lactose forms αH and αS were investigated by time- and temperature-resolved X-ray powder diffractometry and differential scanning calorimetry. We found different X-ray structures for these two forms, which is probably related to the different dehydration processes. The rapidly dehydrated form αH obviously has the same X-ray structure as the starting material α-lactose monohydrate, although the crystallinity is reduced. A thermally induced transition of the αH-form into the αS-form was observed. This transition should allow one to “switch” between the physicochemical properties of the excipient, which may be important for applications in pharmaceutical and food industries. |
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