Spectrophotometric Microdetermination of Some Pharmaceutically Impor tant Aminoquinoline Antimalarials, as Ion-Pair Complexes |
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Authors: | Alaa S Amin Yousry M Issa |
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Institution: | (1) Chemistry Department, Faculty of Science, Benha University, Benha, Egypt, EG;(2) Faculty of Science, Cairo University, Giza, Egypt, EG |
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Abstract: | A simple, rapid, accurate and sensitive spectrophotometric method for the microdetermination of some pharmaceutically important
aminoquinoline antimalarials, namely amodiaquine dihydrochloride (I), chloroquine phosphate (II) and primaquine phosphate
(III) is described. The method is based on the interaction of these drugs with calmagite indicator to give highly coloured
ion-pair complexes which exhibit maximum absorption at 663, 665 and 666 nm, respectively, Beer’s law is obeyed in the concentration
ranges 1.0–25.0, 1.0–28.0 and 1.0–33.0 μg/ml for the drugs I, II and III, respectively. For more accurate analysis, the Ringbom
optimum concentration ranges are 2.5–22.5, 2.0–26.0 and 3.0–30.0 μg/ml, respectively. The apparent molar absorptivities were
calculated. Statistical treatment of the experimental results indicates that the method is sufficiently accurate and precise.
The accuracy of the method is indicated by the recovery (99.8±1.4%) and the precision by the relative standard deviation (>1.5%).
The proposed method has been applied to the determination of these drugs in certain formulations, with results that compared
favourably with those obtained by the official methods.
Received November 2, 1998. Revision February 29, 2000. |
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Keywords: | : Calmagite determination of antimalarial compounds dosage forms |
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