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Configuration-Induced Multichromism of Phenanthridine Derivatives: A Type of Versatile Fluorescent Probe for Microenvironmental Monitoring |
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| Authors: | Wei Huang Dr. Shiyu Feng Jie Liu Baoshuai Liang Ya Zhou Mengya Yu Jiayuan Liang Prof. Jiaguo Huang Prof. Xujie Lü Prof. Weiguo Huang |
| Affiliation: | 1. State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, 155 Yangqiao West Road, Fuzhou, Fujian 350002 P. R. China These authors contributed equally to this work. Contribution: Data curation (lead), Formal analysis (lead), Investigation (lead), Methodology (lead), Validation (lead);2. State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, 155 Yangqiao West Road, Fuzhou, Fujian 350002 P. R. China Fujian Science & Technology Innovation Laboratory for Optoelectronic Information of China, Fuzhou, Fujian 350108 P. R. China University of Chinese Academy of Sciences, 19 A Yuquan Road, Beijing, 100049 P. R. China These authors contributed equally to this work. Contribution: Data curation (lead), Formal analysis (lead), Funding acquisition (lead), Investigation (lead), Methodology (lead), Validation (lead), Visualization (lead);3. State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, 155 Yangqiao West Road, Fuzhou, Fujian 350002 P. R. China These authors contributed equally to this work. Contribution: Data curation (equal), Formal analysis (equal), Investigation (equal), Methodology (equal), Software (equal), Validation (equal), Visualization (equal);4. State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, 155 Yangqiao West Road, Fuzhou, Fujian 350002 P. R. China University of Chinese Academy of Sciences, 19 A Yuquan Road, Beijing, 100049 P. R. China Contribution: Data curation (supporting), Formal analysis (supporting), Investigation (supporting), Methodology (supporting), Validation (supporting);5. School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006 P. R. China Contribution: Data curation (supporting), Investigation (supporting), Methodology (supporting);6. School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006 P. R. China Contribution: Data curation (supporting), Formal analysis (supporting), Investigation (supporting), Methodology (supporting);7. Center for High Pressure Science and Technology Advanced Research (HPSTAR), Shanghai, 201203 P. R. China Contribution: Data curation (supporting), Formal analysis (supporting), Investigation (supporting), Methodology (supporting);8. School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006 P. R. China Contribution: Data curation (supporting), Formal analysis (supporting), Investigation (supporting), Methodology (supporting), Validation (supporting);9. Center for High Pressure Science and Technology Advanced Research (HPSTAR), Shanghai, 201203 P. R. China Contribution: Data curation (supporting), Formal analysis (supporting), Investigation (supporting), Methodology (supporting), Validation (supporting);10. State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, 155 Yangqiao West Road, Fuzhou, Fujian 350002 P. R. China |
| Abstract: | Fluorescent probes are attractive in diagnosis and sensing. However, most reported fluorophores can only detect one or few analytes/parameters, notably limiting their applications. Here we have designed three phenanthridine-based fluorophores (i.e., B1 , F1 , and T1 with 1D, 2D, and 3D molecular configuration, respectively) capable of monitoring various microenvironments. In rigidifying media, all fluorophores show bathochromic emissions but with different wavelength and intensity changes. Under compression, F1 shows a bathochromic emission of over 163 nm, which results in organic fluorophore-based full-color piezochromism. Moreover, both B1 and F1 exhibit an aggregation-caused quenching (ACQ) behavior, while T1 is an aggregation-induced emission (AIE) fluorophore. Further, F1 and T1 selectively concentrate in cell nucleus, whereas B1 mainly stains the cytoplasm in live cell imaging. This work provides a general design strategy of versatile fluorophores for microenvironmental monitoring. |
| Keywords: | Bioimaging Configuration-Induced Multichromism Microenvironmental Monitoring Optical Sensing Phenanthridine Derivatives |