Potentiometric determination of mephedrone in oral fluids with ion-selective membranes |
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| Authors: | Eva Pospíšilová Natálie Paškanová Martin Kuchař Tatiana V. Shishkanova |
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| Affiliation: | 1. Department of Analytical Chemistry, University of Chemistry and Technology, Technická 5, 16628 Prague 6, Czech Republic;2. Forensic Laboratory of Biologically Active Substances, Department of Chemistry of Natural Compounds, University of Chemistry and Technology, Technická 3, 16628 Prague, Czech Republic |
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| Abstract: | This work presents a potentiometric approach for the detection of two cathinone derivatives, namely mephedrone (4-MMC) and clephedrone (4-CMC). Contrary to neutral-carriers (dibenzo-18-crown-6-ether and calix[4]arene), cation-exchanger (tetraphenylborate sodium) as active component of ion-selective membrane showed near-Nernstian response (+47 mV/decade from 1.7 ⋅ 10−6 to 5.6 ⋅ 10−4 mol l−1) and selectivity for 4-MMC in oral fluids (OF). The agreement between the quantitative results obtained with the potentiometric approach and the HPLC/MS-MS method determination of 4-MMC in OF shows the potential of the proposed potentiometric approach for forensic analysis. |
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| Keywords: | ion-selective membranes oral fluid potentiometry synthetic cathinones |
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