Base-Promoted Difunctionalization of Alkynes: One-Pot Synthesis of Polysubstituted Chromones |
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| Authors: | Dr Mengdan Wang Lu Cheng Prof Junying Ma Prof Weiwei Lu Prof Junling Wang |
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| Institution: | 1. School of Chemical Engineering & Pharmaceutics, Henan University of Science and Technology Luoyang, 471003 Henan, P. R. China;2. School of Chemistry and Molecular Engineering, East China Normal University, 500 Dongchuan Road, 200241 Shanghai, P. R. China |
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| Abstract: | A transition-metal-free one-pot procedure for the difunctionalization of alkynes by C?C triple bond oxidation and transformation towards chromone derivatives has been developed. It involves cascade reactions for carbonylation of alkynes, base-promoted C?C σ-bond cleavage, and intramolecular cyclization. This procedure provides an efficient protocol for the synthesis of polysubstituted chromones from readily available starting materials. |
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| Keywords: | difunctionalization of alkynes one-pot transition-metal-free C?C triple bond oxidation synthesis |
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