Quantitative analysis of topical gels and ointments by FT-Raman spectroscopy |
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| Institution: | 1. Institute of Physics, Faculty of Mathematics and Physics, Charles University, Ke Karlovu 5, 121 16 Prague 2, Czech Republic;2. Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Flemingovo náměstí 2, 166 10 Prague 6, Czech Republic;1. Department of Neurobiology, Institute of Pharmacology, Polish Academy of Sciences, Sm?tna 12, 31-343 Kraków, Poland;2. Faculty of Foundry Engineering, AGH University of Science and Technology, ul. Reymonta 23, 30-059 Kraków, Poland;3. Institute of Nuclear Physics, Polish Academy of Science, 31-342 Krakow, Poland;4. Faculty of Chemistry, Jagiellonian University, ul. Ingardena 3, 30-060 Kraków, Poland;5. Department of Chemistry, Hankuk University of Foreign Studies, Yongin, Kyunggi-Do, 449-791, South Korea |
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| Abstract: | A method for quantitative determination of ibuprofen (IBU), naproxen (NAP), methyl salicylate (MES) and menthol (MNT) in commercial topical gels and ointments using partial least squares (PLS) models based on FT-Raman spectra is described. The calculated relative standard errors of prediction (RSEP) were found to be in the range of 2.1–3.2% for the calibration and validation data sets. Two commercial topical gels containing 5.0% of IBU and 10% of NAP (w/w), as well as one ointment containing 15% of MES and 10% of MNT (w/w) as active pharmaceutical ingredients (APIs), were successfully quantified using the developed models with recoveries in the 99.2–101.5% range. The proposed procedure can be used as a fast, reliable and economic method for the quantification of APIs in topical gels and ointments. |
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| Keywords: | Topical gel Ointment Raman spectroscopy Quantitative analysis Multivariate calibration |
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