Trifluoroacetylation of pyrrolo[1,2-<Emphasis Type="Italic">a</Emphasis>]pyrazines |
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Authors: | V I Terenin E V Kabanova N A Tselishcheva A S Ivanov N V Zyk |
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Institution: | (1) Chemistry Faculty, M. V. Lomonosov Moscow State University, Moscow, 119899, Russia |
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Abstract: | A study was carried out on the reaction of pyrrolo1,2-a]pyrazines containing an alkyl, aryl, or aralkyl substituent at C-1
with trifluoroacetic anhydride. Trifluoroacetylation products may be formed either by reaction in the pyrrole ring or at the
aryl or aralkyl groups at C-1. Products of electrophilic substitution at C-6 are formed in the trifluoroacetylation of pyrrolo1,2-a]pyrazines
containing at C-1 a substituent bulkier than a methyl group but lacking substituents at C-6 (the α-position of the pyrrole
ring).
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 8, pp. 1226–1233, August, 2007. |
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Keywords: | pyrrolo[1 2-a]pyrazine trifluoroacetic anhydride trifluoroacetylation |
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