| 泮托拉唑钠的合成工艺改进 |
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| 引用本文： | 俞小弟,楼少杰,金文虎,罗晓燕,许煦,冀亚飞.泮托拉唑钠的合成工艺改进[J].合成化学,2007,15(6):792-794. |
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| 作者姓名： | 俞小弟 楼少杰 金文虎 罗晓燕 许煦 冀亚飞 |
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| 作者单位： | 1. 华东理工大学,药学院,上海,200237
2. 华东理工大学,化工学院,上海,200237 |
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| 摘 要： | 以5-二氟甲氧基-2-巯基-1H-苯并咪唑和2-氯甲基-3,4-二甲氧基吡啶盐酸盐为原料,经缩合,氧化和成盐反应合成了泮托拉唑钠,其结构经1HNMR和MS表征。缩合,氧化和成盐反应的收率分别为88.8%,79.2%,89.7%。
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| 关 键 词： | 泮托拉唑钠 缩合反应 氧化反应 药物合成 工艺改进 |
| 文章编号： | 1005-1511（2007）06-0792-03 |
| 收稿时间： | 2007-05-21 |
| 修稿时间： | 2007年5月21日 |
Process Improvement on the Synthesis of Pantoprazole Sodium |
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| YU Xiao-di,LOU Shao-jie,JIN Wen-hu,LUO Xiao-yan,XU Xu,JI Ya-fei.Process Improvement on the Synthesis of Pantoprazole Sodium[J].Chinese Journal of Synthetic Chemistry,2007,15(6):792-794. |
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| Authors: | YU Xiao-di LOU Shao-jie JIN Wen-hu LUO Xiao-yan XU Xu JI Ya-fei |
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| Institution: | a. School of Pharmacy; b. College of Chemical Engineering, 1. East China University of Science and Technology, Shanghai 200237, China |
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| Abstract: | Pantoprazole sodium was synthesized from 5-difluoromethoxy-2-mercapto-1H-benzimidazole and 2-chloromethyl-3,4-dimethoxypyridine hydrochloride by condensation, oxidation and saltforming. The structure was confirmed by 1H NMR and MS. The yields of the condensation, oxidation and saltforming were 88.8%, 79.2% and 89.7%, respectively. |
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| Keywords: | pantoprazole sodium condensation oxidation sodium perborate drug synthesis process improvement |
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