|
|||||
|
|
SPR Study of the Blocking Activity of Soybean Trypsin Inhibitor by Macrocyclic Complexes of Nickel Immobilized on a Gold Surface |
|
| Authors: | Snopok B A Boltovets P N Tsymbal L V Lampeka Ya D |
| Institution: | (1) V. E. Lashkarev Institute of Semiconductor Physics, National Academy of Sciences of Ukraine, 45 Nauky Prospekt, 03028, Kyiv, Ukraine;(2) L. V. Pisarzhevskii Institute of Physical Chemistry, National Academy of Sciences of Ukraine, 31 Nauky Prospekt, 03028, Kyiv, Ukraine |
| Abstract: | A method is proposed for the modification of metallic gold surfaces by self-organization of a nickel(II) macrocyclic complex containing a thiol substituent. Effective blocking of biologically active soybean trypsin inhibitor by the immobilized complex was observed. The prospects of using the given surface to create sensitive elements for sensors capable of detecting both small molecules (thiocyanate ions) and some protein substrates is demonstrated. |
| Keywords: | nickel macrocyclic complex thiols proteins monolayers |
| 本文献已被 SpringerLink 等数据库收录！ | |