2,3-disubstituted benzofuran and indole by copper-mediated C-C bond extension reaction of 3-zinciobenzoheterole |
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| Authors: | Nakamura Masaharu Ilies Laurean Otsubo Saika Nakamura Eiichi |
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| Institution: | Department of Chemistry, The University of Tokyo, Hongo, Bunkyo-ku, Japan. masaharu@scl.kyoto-u.ac.jp |
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| Abstract: | reaction: see text] A metalative 5-endo-dig cyclization reaction of 2-ynylphenoles or anilines effected by BuLi and ZnCl(2) produces 3-zinciobenzoheteroles in excellent yield. These intermediates have been transmetalated to the corresponding cuprates and allowed to react with electrophiles to produce a variety of 2,3-disubstituted benzofurans and indoles. |
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