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Total synthesis of pleurolactone |
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| Authors: | Toyoharu Kobayashi Masako Ishida Kazuhiro Imaida Hideki Abe Hisanaka Ito |
| Affiliation: | School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan |
| Abstract: | The stereoselective total synthesis of pleurolactone has been accomplished in 7 steps. The key synthetic features were the construction of four contiguous stereocenters using an endo-selective Diels-Alder reaction and high diastereoselective dihydroxylation. |
| Keywords: | Terpenoids Pleurolactone Diels-Alder reaction Diastereoselective dihydroxylation Hexahydrobenzofuran |
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