Synthesis of structure-defined branched hyaluronan tetrasaccharide glycoclusters |
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| Authors: | Meng Sha Wang Yao Xiao Zhang Zhongjun Li |
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| Affiliation: | State Key Laboratory of Natural and Biomimetic Drugs, Department of Chemical Biology, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China |
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| Abstract: | Hyaluronan is a glycosaminoglycan with a large number of biological activity. Hyaluronan of different molecular weight often shows different biological activity, sometimes even completely opposite, but the mechanism is not clear. Herein, the hyaluronan tetrasaccharide glycoclusters using hyaluronan tetrasaccharide obtained by enzymolysis of natural hyaluronan were firstly synthesized in high yield. The structurally determined and diverse glycoclusters were of wide molecular weight range and might be used for mimicking the biological activity of natural hyaluronan and facilitating the mechanism study. |
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| Keywords: | Hyaluronan Hyaluronidase Glycocluster Glycomimetic Large-scale enzymatic production |
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