Toward a highly sensitive and selective indole-rhodamine-based light-up probe for Hg2+ and its application in living cells |
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Authors: | Yao Tang Guo-Fang Jiang |
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Affiliation: | State Key Lab of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, PR China |
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Abstract: | We herein designed and synthesized a light-up fluorescent probe L1 for Hg2+ species, which is based on indole derivative and Rhodamine fluorophore. The new probe can show a linear response to Hg2+ with high sensitivity and selectivity. As the Hg2+ concentration changed from 0 to 450 μM, the fluorescence intensity of L1 at 575 nm changed from 50 to 6181 (~120-fold). The detection limit of the probe was 5.0 × 10?8 M. Besides, we have successfully applied L1 to monitor Hg2+ species in living MCF-7 cells by way of fluorescence imaging. |
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Keywords: | Fluorescent probe Sensitivity Selectivity Cell imaging |
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