Recent advances in the enantioselective 1,3-dipolar cycloaddition of azomethine ylides and dipolarophiles |
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| Authors: | Bilel Bdiri Boa-Jing Zhao Zhi-Ming Zhou |
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| Affiliation: | 1. R&D Centre of Pharmaceuticals, School of Chemical Engineering and the Environment, Beijing Institute of Technology, 5th Zhongguancun South Street, Haidian District, Beijing 100081, China;2. State Key Laboratory of Explosion Science and Technology, Beijing Institute of Technology, 5th Zhongguancun South Street, Haidian District, Beijing 100081, China |
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| Abstract: | The synthesis of diastereo- and enantiopure heterocyclic molecules via catalytic asymmetric 1,3-dipolar cycloaddition reaction between azomethine ylides, generated in situ from α-amino acid-derived iminoesters and dipolarophiles is considered one of the most powerful and versatile techniques. In this review, we make a detailed overview of the latest developments in this area since 2014 and highlight the recent improvements in the structural scope of dipolarophiles, azomethine ylide precursors, and chiral ligands. |
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| Keywords: | Corresponding authors. Tel.: +86 18010009150 (B.B.). Tel./fax: +86 1068928982 (Z.-M.Z.). |
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