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BF3·Et2O catalyzed intramolecular cyclization of diethyl 2-(dialkoxyphosphorylethynyl)-2-arylaminomalonates to 3-phosphonylated indoles |
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| Authors: | Anastasia V Egorova Nikolai B Viktorov Galina L Starova Nataly I Svintsitskaya Aleksandr V Garabadziu Albina V Dogadina |
| Institution: | 1. Saint-Petersburg State Institute of Technology (Technical University), Moskovskii pr. 26, Saint Petersburg 190013, Russia;2. Saint-Petersburg State University, Universitetskii pr. 26, Saint Petersburg 198504, Russia |
| Abstract: | The boron trifluoride diethyl etherate catalyzed intramolecular cyclization of diethyl 2-(dialkoxyphosphorylethynyl)-2-arylaminomalonates afforded a series of novel 3-phosphonylated indoles, diethyl 2-3-(dialkoxyphosphoryl)-1H-indol-2-yl]propanedioates. Decarboxylation of the latter compounds resulted in the formation of ethyl 2-3-(dialkoxyphosphoryl)-1H-indol-2-yl]acetates. |
| Keywords: | RAVDFJHSRAEDHG-UHFFFAOYSA-N GFZLXSCLUPCABR-UHFFFAOYSA-N SZGFNBMAMPUDBU-UHFFFAOYSA-N YETHGOGUWOIOIA-UHFFFAOYSA-N NCYWPSMCWOGSNP-UHFFFAOYSA-N USCGKQNZMMDDED-UHFFFAOYSA-N TZLHJMBEELDPLM-UHFFFAOYSA-N MROGRQUTDZUVII-UHFFFAOYSA-N UJJJEXHDVGHPTB-UHFFFAOYSA-N KKWGHYJMJUBNJG-UHFFFAOYSA-N PECJGKOQWWUACH-UHFFFAOYSA-N VLFHYWSXZJNUKL-UHFFFAOYSA-N Phosphorylated indoles Phosphonylated indoles Aminomalonates Phosphonylated 2-arylaminomalonic esters Decarboxylation |
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