Brønsted acid-mediated cascade cyclization of 2-propynolphenols/anilines leading to 4-halo-2H-chromenes and 1,2-dihydroquinolines |
| |
| Authors: | Ren Li Xian-Rong Song Xi Chen Haixin Ding Qiang Xiao Yong-Min Liang |
| |
| Institution: | 1. Institute of Organic Chemistry, Jiangxi Science & Technology Normal University, Key Laboratory of Organic Chemistry, Jiangxi Province, Nanchang 330013, China;2. State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, China |
| |
| Abstract: | A convenient strategy is present for easy construction of a series of 4-halo-2H-chromenes and 1,2-dihydroquinolines through Brønsted acid-mediated cascade cyclization of readily accessible 2-propynolphenols/anilines. Our developed approaches prove have good functional-group applicabilities and could be enlarged to gram quantities in high yields. Moreover, the resulting halides could be further exploited in subsequent palladium-catalyzed coupling reactions. |
| |
| Keywords: | 2-Propynolphenols/anilines Brønsted acid-mediated Cascade cyclization |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
