Rapid,efficient and solvent-free synthesis of (un)symmetrical xanthenes catalyzed by recyclable sulfated polyborate |
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Authors: | Manisha S. Patil Amey V. Palav Chetan K. Khatri Ganesh U. Chaturbhuj |
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Affiliation: | 1. Department of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, Mumbai 400019, India;2. Loba Chemie Pvt. Ltd., Research and Development Center, Tarapur, Boisar, Thane 401506, India |
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Abstract: | The present study describes a rapid, simple and straightforward approach to the synthesis of 1,8-dioxo-octahydroxanthenes, 14-phenyl-14H-dibenzo[a,j]xanthene and tetrahydrobenzoxanthene-11-ones under solvent-free conditions using sulfated polyborate as a highly efficient catalyst. The procedure offers several advantages including cleaner reaction profile, mild reaction condition, economic, recyclable and environmentally benign catalyst, high yields, simple experimental and workup procedures. While non-extractive work up/purification, along with reusability of catalyst make this method economically affordable for large scale. |
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Keywords: | Sulfated polyborate Xanthenes Dimedone Aldehyde β-Naphthol |
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