A practical method,NaOCl-mediated,to prepare thiabendazoles via intramolecular amination reaction |
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| Authors: | Vikrant Patil Enrique Barragan Shivaputra A Patil Siddappa A Patil Alejandro Bugarin |
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| Institution: | 1. Centre for Nano & Material Sciences, Jain University, Jain Global Campus, Bangalore 562112, Karnataka, India;2. Department of Chemistry & Biochemistry, University of Texas at Arlington, Arlington, TX 76019, USA;3. Pharmaceutical Sciences Department, College of Pharmacy, Rosalind Franklin University of Medicine and Science, 3333 Green Bay Road, North Chicago, IL 60064, USA |
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| Abstract: | A series of new chlorinated thiabendazoles (6a–m) have been synthesized from readily available anilines and 4-cyanothiazole in moderate to good yields. All synthesized compounds were fully characterized using 1H NMR, 13C NMR, IR, and mass spectrometry. Additionally, the structure of the compound (6f) was confirmed by single-crystal X-ray diffraction. In addition, synthesis of 2-substituted benzimidazoles and 2-phenyl benzothiazole was investigated using our optimized conditions and the outcome is presented herein. |
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| Keywords: | Thiabendazole Bleach Synthesis Characterization Single-crystal X-ray diffraction |
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