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Two-step total synthesis of an anti-MRSA and myosin-inhibiting marine natural product pentabromopseudilin via Suzuki-Miyaura coupling of a MIDA boronate ester |
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| Authors: | Dong-Young Kum Mohamad Nazari Kerry L. McPhail Christina S. Cooper Takashi L. Suyama |
| Affiliation: | 1. Department of Health Sciences, Corban University, 5000 Deer Park Dr. SE, Salem, OR 97317, United States;2. College of Pharmacy, Oregon State University, Corvallis, OR 97331, United States;3. Physical Science Department, Linn Benton Community College, 6500 SW Pacific Blvd, Albany, OR 97321, United States |
| Abstract: | A marine natural product isolated from Pseudoalteromonas sp., pentabromopseudilin, with promising anti-MRSA and myosin ATPase inhibition activities was synthesized in two steps using recently developed MIDA boronate Suzuki-Miyaura coupling technology. Additionally, bromination was shown to be necessary for the antimicrobial activity of pentabromopseudilin. |
| Keywords: | Suzuki-Miyaura Boronic acid MIDA ester MRSA Brominated pyrrole alkaloid |
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